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KMID : 0358420090520040429
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 4 p.429 ~ p.436
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Clinicopathologic study of ovarian granulosa cell tumors
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Lee In-Ho
Lee Ki-Heon
Kim Tae-Jin
Lim Kyung-Taek
Shim Jae-Uk
Hahn Ho-Suap
Hong Jae-Sik
Kwon Yong-Soon
Mok Jung-Eun
Yoon Seok-Geun
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Abstract
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Objective: The aim of this study was to evaluate the clinicopathologic characteristics of granulosa cell tumor of the ovary (OGCT).
Methods: We retrospectively reviewed the medical records of 27 patients with OGCT at our hospitals from January 1995 to December 2003.
Results: The mean age was 48.3 years (24~70) and mean follow up period was 56.7 months (12~102). The most common symptom was vaginal bleeding (n=11, 40.7%). The tumors were ranging from 3 cm to 21 cm in diameter (mean: 9.9). Post-surgical FIGO stage was stage I in 20 (74.1%), stage II in 6 (22.2%), and stage III in 1 (3.7%). Endoemetrial samples were available in 21 patients and the results were endometrial carcinoma in 1 and endometrial hyperplasias in 5. Staging operation was performed in 17, unilateral salpingo-oophorectomy in 6, total hysterectomy and bilateral salpingo-oophorectomy in 2, and fertility sparing operation in 2. Postoperative chemotherapy was administered in 13 patient (48.2%). Two patients had recurred and recurrence rate was 7.4% (2/27). Two recurred patients finally died of the disease at 42 months and 103 months after first operation respectively. During follow-up period, 2 patients had 3 pregnancies and all of them delivered at term.
Conclusion: These results shows that most OGCT is detected in early stage and have relatively excellent survival. However, because OGCT is a slow-growing tumor and has a late recurrence, long time follow-up is required.
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KEYWORD
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Granulosa cell tumor, Ovary, Clinical study
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